Endostatin: current concepts about its biological role and mechanisms of action.

摘要: Endogenous inhibitors of angiogenesis are proved to be a major factor preventing the emergence clinically manifested stages human cancer. The protein endostatin, 20-kD proteolytic fragment type XVIII collagen, is one most active natural angiogenesis. Endostatin specifically inhibits in vitro and vivo proliferation endothelial cells, inducing their apoptosis through inhibition cyclin D1. On surface endostatin binds with integrin α5β1 that activates Src-kinase pathway. binding integrins also down-regulates activity RhoA GTPase signaling pathways mediated by small kinases Ras Raf families. All these events promote disassembly actin cytoskeleton, disorders cell-matrix interactions, decrease endotheliocyte mobility, i.e., suppression displays high antitumor vivo: it progression more than 60 types tumors. This review summarizes results numerous studies concerning biological action mechanism endostatin.