[Adjuvant therapy with recombinant interferon alfa-2a in metastasized malignant melanoma].

摘要: Recombinant alpha-2a interferon (IFN alpha-2a; Roferon-A) was administered as adjuvant therapy in 21 patients with malignant melanoma stage IIa or IIb after surgical removal of all detectable metastases. Patients received 9 x 10(6) units IFN s.c. 3 times weekly over 6 months. One patient treated 12 Relapses occurred 5 the during therapy, and 10 developed new metastases a few weeks months end therapy. Of 15 recurrent disease, have since died. without any relapse died myocardial infarction start Comparison an untreated historical matched control group did not show prolongation recurrence-free period interferon-treated group.