Harmonization: the Sample, the Measurement, and the Report

摘要: Harmonization of clinical laboratory results means that are comparable irrespective the measurement procedure used and where or when a was made. test includes consideration pre-analytical, analytical, post-analytical aspects. Progress has been made in each these aspects, but there is currently poor coordination effort among different professional organizations countries. Pre-analytical considerations include terminology for order, instructions preparation patient, collection samples, handling transportation samples to laboratory. Key analytical calibration traceability reference system, commutability materials scheme, specificity biomolecule interest. International addressing harmonization Federation Clinical Chemistry Laboratory Medicine, World Health Organization, recently formed Consortium Results (ICHCLR). The ICHCLR will provide prioritization process measurands service coordinate global activities avoid duplication effort. Post-analytical nomenclature, units, significant figures, intervals decision values results. all areas necessary optimal service. This review summarizes status describes underway achieve goal fully harmonized testing.