Prospective Randomized Controlled Trial Comparing the Effects of Noncontact Low-Frequency Ultrasound with Standard Care in Healing Split-Thickness Donor Sites

摘要: Background Skin graft donor sites are notoriously painful, with potential complications of fluid loss, delayed healing, infection, and hypertrophic scarring, particularly in patients burns or traumatic injury. In this population, rapid epithelialization is critical to reducing morbidity cost. Study Design This prospective, randomized controlled trial compared the effects 40-kHz noncontact low-frequency ultrasound (NLFU) addition standard care (SC) SC alone subjects split-thickness 20 200 cm 2 . Standard consisted cleansing moist wound dressings. Outcomes measured were time defined as absence drainage full epithelialization; pain itching scores; recidivism rates. Results Of 33 enrolled; 27 received a minimum 4 study treatments. Median age was 49 years, 69% male, 84% burn patients. Comorbidities included hypertension (31%), coronary artery disease (22%), pulmonary (38%), anemia diabetes (16%). site area 136.0 Noncontact demonstrated mean heal 12.1 days vs 21.3 (p = 0.04). All NLFU+SC had epithelialized by weeks only 71% SC. Recidivism rates 8% for 45% Pain scores reduced significant differences observed. Conclusions treatment accelerated healing itching. experienced better quality less incidence infection recidivism.