作者: Jason R. Richardson , Vanessa Fitsanakis , Remco H. S. Westerink , Anumantha G. Kanthasamy
DOI: 10.1007/S00401-019-02033-9
关键词:
摘要: Pesticides are unique environmental contaminants that specifically introduced into the environment to control pests, often by killing them. Although pesticide application serves many important purposes, including protection against crop loss and vector-borne diseases, there significant concerns over potential toxic effects of pesticides non-target organisms, humans. In cases, molecular target a is shared species, leading for untoward effects. Here, we review history usage neurotoxicity selected classes pesticides, insecticides, herbicides, fungicides, humans experimental animals. Specific emphasis given linkages between exposure risk neurological disease dysfunction in coupled with mechanistic findings animal models. Finally, discuss emerging techniques strategies improve translation from models