SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.
作者： Athanassios Vassilopoulos , J. Daniel Pennington , Thorkell Andresson , David M. Rees , Allen D. Bosley
关键词:
摘要: Abstract Aims: Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases ATP levels. Here, we investigate mechanistic connection between SIRT3 homeostasis. Results: By using both in vitro vivo experiments, demonstrate that F1 proteins alpha, beta, gamma, Oligomycin sensitivity-conferring protein (OSCP) contain SIRT3-specific reversible acetyl-lysines are evolutionarily conserved bind SIRT3. OSCP was further investigated lysine 139 is a nutrient-sensitive SIRT3-dependent deacetylation target. Site directed mutants OSCPK139 directs, at least part, production mice lacking exhibit decreased muscle levels, increased acetylation, an exercise-induced stress-deficient phenotype. Innovation: This work connects aging...
um.edu.mo
sci-hub.se 参考文章(30)
Sergei A. Ezhevsky, Michelle Becker-Hapak, Hikaru Nagahara, Michael C. Wei, Steven F. Dowdy, David R. Gius, Transduced p16INK4a Peptides Inhibit Hypophosphorylation of the Retinoblastoma Protein and Cell Cycle Progression Prior to Activation of Cdk2 Complexes in Late G1 Cancer Research. ,vol. 59, pp. 2577- 2580 ,(1999)
B. Li, M. Gogol, M. Carey, D. Lee, C. Seidel, J. L. Workman, Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science. ,vol. 316, pp. 1050- 1054 ,(2007) , 10.1126/SCIENCE.1139004
Nilanjan Sengupta, Xiaohong Zhang, Edward Seto, Michele A. Glozak, Acetylation and deacetylation of non-histone proteins Gene. ,vol. 363, pp. 15- 23 ,(2005) , 10.1016/J.GENE.2005.09.010
Jérôme Lugrin, Eleonora Ciarlo, Alba Santos, Gaël Grandmaison, Isis Dos Santos, Didier Le Roy, Thierry Roger, The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochimica et Biophysica Acta. ,vol. 1833, pp. 1498- 1510 ,(2013) , 10.1016/J.BBAMCR.2013.03.004
Hyun-Seok Kim, Cuiying Xiao, Rui-Hong Wang, Tyler Lahusen, Xiaoling Xu, Athanassios Vassilopoulos, Guelaguetza Vazquez-Ortiz, Won-Il Jeong, Ogyi Park, Sung Hwan Ki, Bin Gao, Chu-Xia Deng, Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis Cell Metabolism. ,vol. 12, pp. 224- 236 ,(2010) , 10.1016/J.CMET.2010.06.009
S. S. Sundaresan, P. Ramesh, K. Sivakumar, M. N. Ponnuswamy, Purification, crystallization and preliminary X-ray analysis of haemoglobin from ostrich (Struthio camelus) Acta Crystallographica Section F-structural Biology and Crystallization Communications. ,vol. 65, pp. 681- 683 ,(2009) , 10.1107/S1744309109019009
Cuiying Xiao, Hyun-Seok Kim, Tyler Lahusen, Rui-Hong Wang, Xiaoling Xu, Oksana Gavrilova, William Jou, David Gius, Chu-Xia Deng, SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice Journal of Biological Chemistry. ,vol. 285, pp. 36776- 36784 ,(2010) , 10.1074/JBC.M110.168039
Bjoern Schwer, Eric Verdin, Conserved metabolic regulatory functions of sirtuins. Cell Metabolism. ,vol. 7, pp. 104- 112 ,(2008) , 10.1016/J.CMET.2007.11.006
Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zou, Tatsuya Saitoh, Shizuo Akira, Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome Nature Immunology. ,vol. 14, pp. 454- 460 ,(2013) , 10.1038/NI.2550
C. Choudhary, C. Kumar, F. Gnad, M. L. Nielsen, M. Rehman, T. C. Walther, J. V. Olsen, M. Mann, Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions Science. ,vol. 325, pp. 834- 840 ,(2009) , 10.1126/SCIENCE.1175371