摘要: Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival nociceptive neurons during development. Recently, it has been shown to play an important role in function adults. NGF up-regulated after inflammatory injury skin. Administration exogenous either systemically or skin causes thermal hyperalgesia within minutes. Mast cells are considered components action NGF, because prior degranulation abolishes early NGF-induced component hyperalgesia. Substances degranulated by mast include serotonin, histamine, and NGF. Blockade histamine receptors does not prevent The effects blocking serotonin complex cannot be interpretable uniquely as losing its ability induce To determine whether direct effect on dorsal root ganglion neurons, we have begun investigate acute capsaicin responses small-diameter culture. acutely conditions response capsaicin, suggesting that may sensitizing sensory heat (a process thought operate via receptor VR1). We also found ligands trkB (brain-derived neurotrophic neurotrophin-4/5) sensitize afferents elicit Because brain-derived trkA positive transported anterogradely, consider potentially peripheral involved neurotrophin-induced
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