Electron microscopic study on the jejunal mucosa in human cholera.

摘要: Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In absorptive cells, large pseudopod-like cytoplasmic processes deformed microvilli or without (blebs) projected into lumen apical cell surface, interrupting microvillous border. crypts some undifferentiated crypt cells possessed projections which extended lumen. swelling mitochondria, disappearance cristae, an increase in number vesicles Golgi apparatus, and dilatation vesiculation endoplasmic reticulum observed epithelial cells. portion became oedematous Cytoplasmic fragments enclosed plasma membrane, desquamated organelles, secretory granules lying free Marked irregular widening interepithelial spaces jejunal mucoa at midvillous area. Many cystic vacuoles present cytoplasm possibility fluids being transported blood vessels to lumina through spaces, significance these pathological findings human are discussed this study.