Endotoxin scavengers as a therapeutic strategy for sepsis

作者: Steven M. Opal

DOI: 10.1007/978-3-0348-8755-7_14

关键词:

摘要: Bacterial endotoxin remains an important therapeutic target for the treatment of serious infections from Gram-negative bacterial pathogens. Despite recent failures in past clinical trials with novel anti-endotoxin therapies septic shock [1–6], a critical need to improve unacceptably high mortality rate associated systemic organisms. Endotoxin viable innovative regimens as constitutes most microbially-derived mediator shock.

参考文章(66)
E. T. Rietschel, H. Brade, O. Holst, L. Brade, S. Müller-Loennies, U. Mamat, U. Zähringer, F. Beckmann, U. Seydel, K. Brandenburg, A. J. Ulmer, T. Mattern, H. Heine, J. Schletter, H. Loppnow, U. Schönbeck, H.-D. Flad, S. Hauschildt, U. F. Schade, F. Di Padova, S. Kusumoto, R. R. Schumann, Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification Current Topics in Microbiology and Immunology. ,vol. 216, pp. 39- 81 ,(1996) , 10.1007/978-3-642-80186-0_3
James Horton, George A. Pankey, Polymyxin B, colistin, and sodium colistimethate. Medical Clinics of North America. ,vol. 66, pp. 135- 142 ,(1982) , 10.1016/S0025-7125(16)31447-X
S D Wright, CD14 and innate recognition of bacteria. Journal of Immunology. ,vol. 155, pp. 6- 8 ,(1995)
J L Snable, C G Wilde, R W Scott, M N Marra, J E Griffith, Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. Journal of Immunology. ,vol. 144, pp. 662- 666 ,(1990)
N. N. H. Teng, F. K. Stevenson, C. J. Chapman, N. M. Bhat, M. M. Bieber, Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells. Journal of Immunology. ,vol. 151, pp. 5011- 5021 ,(1993)
M Arditi, J Zhou, R Dorio, G W Rong, S M Goyert, K S Kim, Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14. Infection and Immunity. ,vol. 61, pp. 3149- 3156 ,(1993) , 10.1128/IAI.61.8.3149-3156.1993
W A Flegel, M W Baumstark, C Weinstock, A Berg, H Northoff, Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I. Infection and Immunity. ,vol. 61, pp. 5140- 5146 ,(1993) , 10.1128/IAI.61.12.5140-5146.1993
J L Snable, C G Wilde, R W Scott, M S Collins, M N Marra, M B Thornton, The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. Journal of Immunology. ,vol. 148, pp. 532- 537 ,(1992)
RV McCloskey, RC Straube, C Sanders, SM Smith, CR Smith, Treatment of septic shock with human monoclonal antibody HA-1A: A randomized, double-blind, placebo-controlled trial Resuscitation. ,vol. 30, pp. 81- 82 ,(1995) , 10.1016/0300-9572(95)94129-W