IRIS: a method for reverse engineering of regulatory relations in gene networks

摘要: Background The ultimate aim of systems biology is to understand and describe how molecular components interact manifest collective behaviour that the sum single parts. Building a network interactions basic step in modelling complex entity such as cell. Even if gene-gene only partially real networks because post-transcriptional modifications protein regulation, using microarray technology it possible combine measurements for thousands genes into analysis provides picture cell's gene expression. Several databases provide information about known various methods have been developed infer from expression data. However, topology alone not enough perform simulations predictions system will respond perturbations. Rules among parts are needed complete definition behaviour. Another interesting question integrate carried by topology, which can be derived literature, with large-scale experimental