Ratio of Aβ42/P-tau181p in CSF is associated with aberrant default mode network in AD
作者： Xiaozhen Li , Tie-Qiang Li , Niels Andreasen , Maria Kristoffersen Wiberg , Eric Westman
DOI: 10.1038/SREP01339
关键词:
摘要: The default mode network (DMN) is particularly relevant to Alzheimer's disease (AD) since its structures are vulnerable deposition of amyloid. Decreased levels β-amyloid1-42 (Aβ42) and increased total tau protein (T-tau) phosphorylated at position threonine 181 (P-tau181p) in cerebrospinal fluid (CSF) have been established as valid biomarkers for the diagnosis prognosis AD. However, relationship between CSF change DMN still unknown. In this study we investigated correlation functional connectivity within ratio Aβ42/P-tau181p CSF. We found that was moderately positively correlated with left precuneus/cuneus. This finding implicates brain affected by pathological changes early stage may provide a better understanding AD pathology progression improve diagnosis.
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