Endothelial lipase is a major determinant of HDL level.

摘要: A new member of the lipase gene family, initially termed endothelial (gene nomenclature, LIPG; protein, EL), is expressed in a variety different tissues, suggesting general role lipid metabolism. To assess hypothesis that EL plays physiological lipoprotein metabolism vivo, we have used targeting native murine locus and transgenic introduction human LIPG mice to modulate level expression. Evaluation these alleles C57Bl/6 background revealed an inverse relationship between HDL cholesterol Fasting plasma was increased by 57% LIPG–/– 25% LIPG+/– decreased 19% as compared with syngeneic controls. Detailed analysis particle composition indicated this increase due primarily number particles. Phospholipase assays primary contributor phospholipase activity mouse. These data indicate expression levels novel significant effect on