Long non‑coding RNA LINC01006 exhibits oncogenic properties in cervical cancer by functioning as a molecular sponge for microRNA‑28‑5p and increasing PAK2 expression.

摘要: As previously reported, long intergenic non‑protein‑coding RNA 1006 (LINC01006) plays crucial roles in prostate, pancreatic and gastric cancers. However, whether it important cervical cancer remains unclear. The present study thus aimed to determine the precise role of LINC01006 elucidate its regulatory mechanisms. expression was examined by reverse transcription‑quantitative polymerase chain reaction. Cell proliferation assay, flow cytometric analysis, Transwell migration invasion assays, tumor xenograft model experiments were performed cancer. Bioinformatics luciferase reporter immunoprecipitation rescue for mechanistic analyses. found be upregulated associated with a poor prognosis. absence inhibited proliferation, cells, whereas promoted cell apoptosis vitro. downregulation impeded growth vivo. verified as an endogenous 'sponge' that competed microRNA‑28‑5p (miR‑28‑5p), which resulted upregulation miR‑28‑5p target P21‑activated kinase 2 (PAK2). Rescue revealed suppression or overexpression PAK2 abrogated effects on malignant cellular functions On whole, demonstrates exhibits tumor‑promoting via regulation miR‑28‑5p/PAK2 axis. These findings may provide basis identification LINC01006‑targeted clinical therapy.