Mitochondrial Function and Disturbances in the Septic Kidney

摘要: Per milligram of tissue, only the heart exceeds kidney's abundance mitochondria. Not surprisingly, renal mitochondria are most densely concentrated in epithelium nephron, at sites where chemical work moving solutes against electrochemical gradients places large and constant demands for adenosine triphosphate. Derangements epithelial appear to be a hallmark diverse forms acute kidney injury (AKI). The pathogenesis multiple-organ dysfunction syndrome sepsis is complex, but substantial body experimental observational human data supports twin concepts that mitochondrial contributes impaired filtration recovery structure function essential from sepsis-associated AKI. These insights have suggested novel methods diagnose, stratify, prevent, or even treat this common deadly complication critical illness. This review will do following: (1) describe functions healthy how energy metabolism relates solute transport; (2) provide an overview evidence linking pathology disease; (3) summarize lesions observed septic AKI; (4) analyze role processes including fission/fusion, mitophagy, biogenesis development AKI (5) explore potential therapeutically targeting prevent