Chemokine Receptors as Therapeutic Targets in HIV Infection

摘要: Acquired immunodeficiency syndrome (AIDS) evolved into a pandemic in less than decade since the first reports of new set symptoms that included severe opportunistic infections and unusual neoplasms, particularly Kaposi's sarcoma, homosexual men [1]. Nearly 30 years discovery causative agent [2, 3], human virus (HIV) cannot still be eradicated, nor is there sight safe effective prophylactic vaccine horizon. Infection with either type invariably leads to AIDS; however, pathogenic HIV-2 stains have been geographically restricted mainly West Africa, whilst more virulent HIV-1 strains spread around globe causing AIDS [4]. The worst afflicted region sub-Saharan where few countries one five adults infected virus; at same time, epidemic spreading most rapidly Eastern Europe Central Asia, number people living HIV increased by 250% between 2001 2010 [5]. Worldwide, an estimated 34 million people, including 3.4 children, were end 2010, while related deaths 1.8 2.7 million, respectively