Determination of plasma cholesterol sulfate by LC–APCI-MS/MS in the context of pediatric autism
作者： Bonnie Mei-Wah Fong , Sidney Tam , Kelvin Sze-Yin Leung
DOI: 10.1016/J.TALANTA.2013.04.075
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摘要: Abstract Cholesterol sulfate (CS) has various biological functions. Previously, plasma CS was measured primarily as a means to diagnose X-linked ichthyosis; however, recent hypothesis suggests that deficiency might be related autism. As such, an assay capable of measuring both very high (in the case ichthyosis) and low autism) levels is required. Here we describe novel LC–APCI-MS/MS method for determination in human plasma, propose normal ranges children, based on studies local population Chinese children between ages 2 10. In addition, have used this measure autistic children. isolated by solid-phase extraction, quantified isotope-dilution negative ion mode monitoring 465.3>97.1 m/z 472.3>97.1 (CS- d 7). Mean recovery ranged from 88.1 112.7%; within- between-run imprecisions CVs less than 7.2 8.1%, respectively. The linear up at least 100 µmol L −1 . reference interval males (range: 1.16–4.23 µmol L ) found higher females 0.86–3.20 µmol L ). Comparison showed no statistically significant difference level. conclusion, robust developed, pediatric derived applying
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