Peptide substrates recognisable by a botulinum toxin a, bont/a and the use thereof
作者： Bernard Pierre Roques , Marie-Claude Fournie-Zaluski
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摘要: The invention relates to a peptide substrate selectively recognisable by botulinum toxin A, BoNT/A comprising Nop-(Z)-Pya fragment in the structure thereof, wherein Z is an aminoacid chain, preferably RA and said cleaved toxin. Said also use, particular for carrying out methods detecting, identifying and/or dosing A at very low concentrations (of order of 20 pg) or inhibitors activators metallopeptidase activity, thereby making it possible quantify power thereof.
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