作者: Katharina Specht
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摘要: Dystonias involving masticatory muscles -A retrospective analysisBackround: In this study we report about experiences with clinical aspects of oromandibular dystonias (OMD) respectively Meige-Syndrome regarding our therapy modalities. We retrospectively analysed datas OMD-patients in regard etiological and characteristics as well applied treatment modalities botulinum toxin A injections (BTX-A) the resulting effects. Material methods: 24 patients OMD or Meige-Syndrom that were treated ENT-Department University Gottingen between 1998 2010. Besides demographic evaluation patient population also results injection based on a subjective determined effect-Score, duration side Results: There was 4:1 female preponderance (80% woman, 20% men). 14 identified Meige-Syndrome, only 10 diagnosed to have an isolated OMD. As both forms conducted adult-onset record high mean age 64,71 years onset 51,62 years. According established classification dystonias, 83,33% had primary dystonia 16,66% secondary dystonia. Corresponding definition diseases showed involuntary, repetetive contractions periocular, perioral muscles. Further there several cases involvement neck region although tongue submental complex. accordance symptoms repeatedly injected affected whereas doses slightly lower than those recommended literature. recorded rate effects 8,21% effect 8,71 weeks. The majority (79,16%) reported subjectively perceived improvement their after BTX-injections. Conclusions: Compared ! populations other studies reports are many correspondences ours Meige-Syndrome. can demonstrate is possibility effective low BTX-injections into involved accompanied suitable