Analysis of the Prognostic Significance of Microscopic Margins in 2,084 Localized Primary Adult Soft Tissue Sarcomas

作者: Alexander Stojadinovic , Denis H. Y. Leung , Axel Hoos , David P. Jaques , Jonathan J. Lewis

DOI: 10.1097/00000658-200203000-00015

关键词:

摘要: Several relevant prognostic factors have been defined for soft tissue sarcoma (STS). Three of these factors—tumor size, depth relative to the superficial investing muscular fascia, and histologic grade—have incorporated into recent stage classification system American Joint Committee on Cancer (AJCC). 1 The current staging does not incorporate other that proven significance survival, including anatomic site, positive microscopic surgical margins, presentation with locally recurrent disease. 2 A previous report clinical pathologic based a large population patients primary extremity sarcoma. 2 Factors predictive disease-specific death in study included tumor size 10 cm or more, high grade, deep location, local recurrence, margin. Positive margins were associated increased risk recurrence addition an tumor-related rate. The may be generalizable sites than extremity. In we focus issue extend analysis all initially treated localized STS. aim was define margin after treatment site-specific basis, as well its influence over relapse-free survival rates. This conducted large, well-characterized patient cohort consecutively followed up at single institution specializing

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