Differential Effect of Hydrogen Peroxide and Superoxide Anion on Apoptosis and Proliferation of Vascular Smooth Muscle Cells

摘要: Background Proliferation and apoptosis of vascular smooth muscle cells (VSMCs) are two important components atherosclerosis, restenosis, hypertension. Although reactive oxygen species have been demonstrated to participate in the pathogenesis these diseases, their precise involvement has not fully understood. We hypothesized that different exert distinct effects on proliferation VSMCs. Methods Results Cultured rat VSMCs were exposed xanthine oxidase/xanthine (XO/X) or H2O2-Fe(II). A single exposure XO/X predominantly resulted cell proliferation, whereas frequent exposures high levels death. Administration superoxide dismutase catalase revealed O2− but H2O2 was mitogenic VSMCs, responsible for VSMC Treatment with H2O2-Fe(II) alone presence hydroxyl radical scavengers showed death occurred a dose-dependent manner ...