p53-Dependent pathways in neurite outgrowth and axonal regeneration.
作者： Simone Di Giovanni , Khizr Rathore
DOI: 10.1007/S00441-011-1292-5
关键词:
摘要: The tumor suppressor p53 is a multifunctional sensor of number cellular signals and pathways essential for cell biology, including DNA damage, cycle regulation, apoptosis, angiogenesis metabolism. In the last few years, novel role in neurobiology has emerged, which includes regulation neurite outgrowth axonal regeneration. integrates extracellular that involve neurotrophins axon guidance cues to modulate cytoskeletal response associated with at both transcriptional post-translational level. Here, we review our current knowledge this topic speculate about future research directions related molecular might advance understanding regeneration
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