Circadian clocks in mammalian reproductive physiology: effects of the "other" biological clock on fertility.

摘要: As a discipline, chronobiology has come of age in the last 25 years. There been an exponential increase our understanding molecular mechanism underlying circadian rhythms gene expression, physiology, and behavior. While mammalian clock not yet fully described, most primary gears have probably identified; however, there remains large submerged portion this physiological iceberg. What is extent "clock-controlled gene" expression myriad cell types mammals? are specific processes that depend either directly or indirectly on clock? These questions remain largely unanswered, but recent advances suggest substantial link between basic function physiology several systems. In reproductive system, surge research neuroendocrine endocrine tissues. This makes sense priori, given established clock, behavior (including behavior), physiology. By role we can begin to explore its onset progression diseases negatively affect fertility. Advances area will certainly yield novel insights into etiology these disorders may provide new exciting avenues for clinical reproduction