Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment.
作者： Belinda van Zyl , Denise Tang , Nikola A Bowden
DOI: 10.1530/ERC-17-0336
关键词:
摘要: Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced disease stages and recurrence as result platinum chemotherapy resistance. High-grade serous ovarian (HGSOC), the most common subtype, is conventionally treated with surgery paclitaxel/carboplatin chemotherapy. Initial response are 60-80%, but eventually majority patients become platinum-resistant subsequent relapses. Extensive research on individual biomarkers resistance revealed many potential targets for development new treatments. While this ongoing, there also epigenetic, DNA repair, genome immune changes characterised in HGSOC that can be targeted current therapies. This review discusses focus targetable alternative treatment combinations those currently used. After decades focused elucidating biological cause resistance, future needs using knowledge overcome cancer.
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