Clinical Use of Buprenorphine for Anesthesia and Pain Management in Japan

摘要: Buprenorphine (BUP) is a classic analgesic drug, and recent studies have reported new, unique pharmacological profile of it. BUP can be used in patients with renal dysfunction failure, these receive the same dose administered to those normal function. may local anestheticlike effect blockade voltage gated Na+ channels; it as anesthetic peripheral nerve block adjuvant prolong analgesia. useful for postoperative pain relief severe liver Japan. However, prolonged metabolism occurrence delayed emergence from anesthesia occur patients. Moreover, Japan, transdermal buprenorphine patch (TBP) reducing intractable chronic non-cancer such low back or caused by osteoarthritis not opioid addiction.