Phosphatidylinositol-3-kinase pathway biomarkers
作者： Charles Michael Zacharchuk , Andrew Louis Strahs , Jay Marshall Feingold , Anna Berkenblit , Daniel Stephen Johnston
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摘要: Methods for treating breast cancer, specifically cancers resistant to treatment with one or more known cancer drugs, and related patient selection strategies predicting response drug therapy, such including detecting the presence absence in a of PIK3CA gene amplification, mutation PIK3CA, decrease PTEN protein expression, positive same by administering subject pan-ErbB tyrosine kinase inhibitor.
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