Attenuated pseudorabies virus which has a deletion in at least a portion of a repeat sequence and vaccine containing same

作者: Meng-Fu Shih , Richard D. Macdonald , Mark D. Cochran

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摘要: Attenuated pseudorabies viruses are provided which comprise DNA including a sequence essential for replication of the attenuated virus, at least portion is present in naturally-occurring from repeat has been deleted. These useful as vaccines immunizing animals against virus disease. The invention also provides methods preparing viruses.

参考文章(2)
Antonius Jozef Maria Berns, Arnold Leonard Jozef Gielkens, Deletion mutant of a herpesvirus and vaccine containing said virus ,(1984)
Saul Kit, Malon Kit, Modified live pseudorabies viruses ,(1983)