Direct enantioselective amination of α-ketoester catalyzed by tertiary amine thiourea: a new approach to chiral α-hydroxy-β-amino acid
作者： Ji-Ya Fu , Qi-Lin Wang , Yong-Yuan Gui , Li-Xin Wang
DOI: 10.1016/J.TETLET.2015.05.061
关键词:
摘要: Abstract A highly enantioselective amination of α-ketoesters catalyzed by chiral tertiary amine thioureas was reported to afford α-hydroxy-β-amino acids with two continuous stereocenters in high yields (up 90%) and enantioselectivities 93% ee).
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