Inhaled drug treatment for tuberculosis: Past progress and future prospects

摘要: Since the 1990s rising incidence of multiple drug resistant TB, particularly in context human immunodeficiency virus co-infected patients, has threatened global TB control. At that time funding agencies began to support formal investigation aerosol therapy which until then had been subject case reports individual investigators. Over last decade, proponents have increased number within research community as and extremely dramatically around world. Aerosol offers potential deliver at target concentrations directly into lungs, use alveolar-capillary interface achieve systemic levels, while reducing risk toxicity seen with parentally administered doses. In addition, there are insufficient new drugs pipeline anticipate appearance a regimen assure future control resistance. Consequently, alternative strategies critical achieving control, inhaled therapies should be considered one such strategy.