The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

作者: B. C. S. Cross , P. J. Bond , P. G. Sadowski , B. K. Jha , J. Zak

DOI: 10.1073/PNAS.1115623109

关键词:

摘要: IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation …

参考文章(46)
Anne Bertolotti, Yuhong Zhang, Linda M. Hendershot, Heather P. Harding, David Ron, Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Nature Cell Biology. ,vol. 2, pp. 326- 332 ,(2000) , 10.1038/35014014
Babal Kant Jha, Irina Polyakova, Patricia Kessler, Beihua Dong, Benjamin Dickerman, Ganes C. Sen, Robert H. Silverman, Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity * Journal of Biological Chemistry. ,vol. 286, pp. 26319- 26326 ,(2011) , 10.1074/JBC.M111.253443
Andreas M. Reimold, Neal N. Iwakoshi, John Manis, Prashanth Vallabhajosyula, Eva Szomolanyi-Tsuda, Ellen M. Gravallese, Daniel Friend, Michael J. Grusby, Frederick Alt, Laurie H. Glimcher, Plasma cell differentiation requires the transcription factor XBP-1 Nature. ,vol. 412, pp. 300- 307 ,(2001) , 10.1038/35085509
Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl, GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation Journal of Chemical Theory and Computation. ,vol. 4, pp. 435- 447 ,(2008) , 10.1021/CT700301Q
Hiderou Yoshida, Toshie Matsui, Akira Yamamoto, Tetsuya Okada, Kazutoshi Mori, XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Cell. ,vol. 107, pp. 881- 891 ,(2001) , 10.1016/S0092-8674(01)00611-0
Douglas J Mahoney, Charles Lefebvre, Kristina Allan, Jan Brun, Cina A Sanaei, Stephen Baird, Nelson Pearce, Susanna Grönberg, Brian Wilson, Mikael Prakesh, Ahmed Aman, Methvin Isaac, Ahmed Mamai, David Uehling, Rima Al-Awar, Theresa Falls, Tommy Alain, David F Stojdl, None, Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. Cancer Cell. ,vol. 20, pp. 443- 456 ,(2011) , 10.1016/J.CCR.2011.09.005
R. Luke Wiseman, Yuhong Zhang, Kenneth P.K. Lee, Heather P. Harding, Cole M. Haynes, Joshua Price, Frank Sicheri, David Ron, Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. ,vol. 38, pp. 291- 304 ,(2010) , 10.1016/J.MOLCEL.2010.04.001
Alexei V. Korennykh, Pascal F. Egea, Andrei A. Korostelev, Janet Finer-Moore, Chao Zhang, Kevan M. Shokat, Robert M. Stroud, Peter Walter, The unfolded protein response signals through high-order assembly of Ire1. Nature. ,vol. 457, pp. 687- 693 ,(2009) , 10.1038/NATURE07661
Marcella Calfon, Huiqing Zeng, Fumihiko Urano, Jeffery H. Till, Stevan R. Hubbard, Heather P. Harding, Scott G. Clark, David Ron, IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Nature. ,vol. 415, pp. 92- 96 ,(2002) , 10.1038/415092A