Chemical Functionalization of Solid-State Nanopores and Nanopore Arrays and Applications Thereof

摘要: Chemical functionalization of solid-state nanopores and nanopore arrays applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic in thin membranes with sub-nanometer resolution. A new class chemically modified sensors provided two approaches for monolayer coating by: (1) self-assembly from solution, which -10 nm diameter can be reproducibly coated, (2) under voltage-driven electrolyte flow, 5 may coated. Applications including: the detection biopolymers such as DNA RNA; immobilizing enzymes or other proteins generating chemical gradients; localized pH sensing.