Identification of 12 genetic loci associated with human healthspan
作者： Aleksandr Zenin , Yakov Tsepilov , Sodbo Sharapov , Evgeny Getmantsev , L. I. Menshikov
DOI: 10.1038/S42003-019-0290-0
关键词:
摘要: Aging populations face diminishing quality of life due to increased disease and morbidity. These challenges call for longevity research focus on understanding the pathways controlling healthspan. We use data from UK Biobank (UKB) cohort observe that risks major chronic diseases exponentially double every eight years, i.e., at a rate compatible with Gompertz mortality law. Assuming aging drives acceleration in morbidity rates, we build risk model predict age end healthspan depending age, gender, genetic background. Using sub-population 300,447 British individuals as discovery cohort, identify 12 loci associated whole-genome significance level. find strong correlations between all-cause mortality, life-history, lifestyle traits. thereby conclude offers promising new way interrogate genetics human longevity. Aleksandr Zenin et al. present genome-wide association study healthspan, length morbidity-free life. They osbserve life-history traits, such obesity smoking.
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