Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studies

摘要: OBJECTIVE: The frequently observed U-shaped relationship between body mass index (BMI; kg/m2) and mortality rate may be due to the opposing effects of fat (FM) fat-free (FFM) components BMI on rate. purpose is test hypothesis stated above. DESIGN: Longitudinal prospective cohort studies. follow-up first second National Health Nutrition Examination Surveys (NHANES I NHANES II). SUBJECTS: A total 10 169 male subjects aged 25–75 who participated in II were selected for analyses. Follow-up continued until 1992. mean time was 14.6 y 12.9 y II. Ninety-eight percent participants successfully followed representing a 3722 deaths. MEASUREMENTS: Subscapular triceps skinfolds thickness used as FM indicators, whereas upper arm circumference FFM indicator. Cox proportional hazards model tested relationships BMI, with all-cause adjusting age, smoking status, race education levels. RESULTS: had mortality, nadir approximately 27 kg/m2. However, when indicators added model, became more nearly monotonic increasing. Moreover, indicator increasing decreasing. CONCLUSION: These results support that apparently deleterious marked thinness low that, over range data, leanness (as opposed thinness) has beneficial effects.