Adsorption of Fibrinogen on Silica Surfaces-The Effect of Attached Nanoparticles.

摘要: When a biomaterial is inserted into the body, proteins rapidly adsorb onto its surface, creating conditioning protein film that functions as link between implant and adhering cells. Depending on nano-roughness of will in different amounts, with conformations orientations, possibly affecting subsequent attachment cells to surface. Thus, modifications surface nanotopography an may prevent biomaterial-associated infections. Fibrinogen particular importance since it contains adhesion epitopes are recognized by both eukaryotic prokaryotic cells, can therefore influence bacteria. The aim this study was model adsorption fibrinogen smooth or nanostructured silica surfaces attempt further understand how affect orientation adsorbed molecule. We used coarse-grained model, where main body (visible crystal structure) modeled rigid flexible α C-chains (not visible were completely disordered. found elongated molecule preferably adsorbs such way protrudes solution compared flat one. This implicates increases bio-availability.