Experience-dependent expression of miR-132 regulates ocular dominance plasticity

作者: Paola Tognini , Elena Putignano , Alessandro Coatti , Tommaso Pizzorusso

DOI: 10.1038/NN.2920

关键词:

摘要: miR-132 is a CREB-induced microRNA that involved in dendritic spine plasticity. We found visual experience regulated histone post-translational modifications at CRE locus important for miR-212 and cluster transcription, expression the cortex of juvenile mice. Monocular deprivation reduced contralateral to deprived eye. Counteracting this reduction with an infusion chemically modified mimic oligonucleotides completely blocked ocular dominance

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