β-Lactoglobulin–chlorogenic acid conjugate-based nanoparticles for delivery of (−)-epigallocatechin-3-gallate
作者： Yuting Fan , Yuzhu Zhang , Wallace Yokoyama , Jiang Yi , None
DOI: 10.1039/C6RA28462K
关键词:
摘要: β-Lactoglobulin (BLG)–chlorogenic acid (CA) conjugates were generated by a free radical induced grafting method. BLG–CA showed better antioxidant activities than BLG. The activity increased with the increase of CA substitution. particle sizes (−)-epigallocatechin-3-gallate (EGCG)-loaded nanoparticles prepared anti-solvent method 110.3, 107.4, and 105.8 nm for BLG, (low), (high), respectively. encapsulation efficiencies EGCG in conjugate (high) 72.9%, 71.8%, 73.5%, chemical stabilities both significantly higher BLG nanoparticles. retention (low) simulated gastrointestinal digestion fluid. Little was released under gastric digestion. release less that nanoparticles, indicating conjugating protected from digestive enzymes.
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