Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin.
作者： Masaaki Iwaki , Kazunari Kamachi , Nikolaus Heveker , Toshifumi Konda
DOI: 10.1128/IAI.67.6.2763-2768.1999
关键词:
摘要: The effect of Bordetella pertussis adenylate cyclase toxin (ACT) on platelet aggregation was investigated. This cell-invasive completely suppressed ADP (10 μM)-induced rabbit platelets at 3 μg/ml and strongly thrombin (0.2 U/ml)-induced 10 μg/ml. suppression accompanied by marked increase in intracellular cyclic AMP (cAMP) content diminished the anti-ACT monoclonal antibody B7E11. A catalytically inactive point mutant ACT did not show suppressive effect. Since an cAMP is a known cause dysfunction, these results indicate that observed inactivation due to catalytic activity through cAMP.
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