Methyl Phenyl Selenide Causes Heme Biosynthesis Impairment and Its Toxicity Is Not Modified by Dimethyl Sulphoxide In Vivo

摘要: Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment the heme biosynthesis pathway. Such inhibit sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved biosynthetic pathway, leading to decrease syntheses hemoglobin, cytochromes and other heme-proteins. Methyl phenyl selenide (CH3SePh) has chemopreventive activity against cancer rodents, raising possibility therapeutic use this compound by humans. Treatment with methyl (500 micromol/kg/day, 30 days) inhibited adult male mice. Furthermore, exposure caused an increase liver/body weight ratio hemoglobin content when compared control animals. The vehicle used (DMSO or corn oil) did not affect any analyzed parameters effects towards these parameters. In summary, results presented here support that potential target CH3SePh, content, endpoint.