Gastrointestinal manifestations of mitochondrial disorders: a systematic review.

摘要: Mitochondrial disorders (MIDs) due to respiratory-chain defects or nonrespiratory chain are usually multisystem conditions [mitochondrial multiorgan disorder syndrome (MIMODS)] affecting the central nervous system (CNS), peripheral system, eyes, ears, endocrine organs, heart, kidneys, bone marrow, lungs, arteries, and also intestinal tract. Frequent gastrointestinal (GI) manifestations of MIDs include poor appetite, gastroesophageal sphincter dysfunction, constipation, dysphagia, vomiting, gastroparesis, GI pseudo-obstruction, diarrhea, pancreatitis hepatopathy. Rare dry mouth, paradontosis, tracheoesophageal fistula, stenosis duodeno-jejunal junction, atresia imperforate anus, liver cysts, pancreas lipomatosis, pancreatic congenital obstruction tract, recurrent bowel perforations with intra-abdominal abscesses, postprandial abdominal pain, diverticulosis, pneumatosis coli. Diagnosing involvement in M...