Regional microglial activation in the substantia nigra is linked with fatigue in MS.

摘要: Objective The goal of our study is to assess the role microglial activation in MS-associated fatigue (MSAF) using [F-18]PBR06-PET. Methods Fatigue severity was measured Modified Impact Scale (MFIS) 12 subjects with MS (7 relapsing-remitting and 5 secondary progressive) 10 healthy control participants who underwent MFIS provides a total score as well physical, cognitive, psychosocial subscale scores. Standardized Uptake Value (SUV) 60–90 minute frame PET maps were coregistered 3T MRI. Voxel-by-voxel analysis Statistical Parametric Mapping atlas-based regional analyses performed. SUV ratios (SUVRs) global brain normalized. Results Peak voxel-based level significance for correlation between uptake localized right substantia nigra (T-score 4.67, p = 0.001). Similarly, SUVRs derived from segmentation showed significant (r 0.76, 0.004). On multiple regression, an independent predictor (p 0.02) cognitive values 0.007), after adjustment age, disability, depression. Several additional areas correlations scores identified, including parahippocampal gyrus, precuneus, juxtacortical white matter (all Conclusion Substantia linked MS. Microglial across key regions may represent unifying mechanism MSAF, further evaluation neuroimmunologic basis MSAF warranted.