Evaluation of oxyclozanide and niclosamide combination as alternative antiparamphistomal therapy in buffaloes

作者: Eman K. Bazh , Kadry M. Sadek , H Shaheen

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摘要: Paramphistomiasis causes enteritis and anemia in livestock result substantial production economic losses. It is considered a neglected tropical disease, with lower effective trematodicidal compound for treatment. Keeping view the importance of present study aims to evaluate efficacy oxyclozanide niclosamide, as well combination both drugs treatment Paramphistomum infection. Twenty buffalo males native breed between eight months 2 years age, naturally infected Paramphistomes were treated. Oxyclozanide niclosamide administered 20 ml/100 kg 125 mg/kg orally, respectively. The efficacies estimated on bases reduction body weight, drug efficacy, paramphistomes egg count per gram feces, as, hematological biochemical parameters. obtained results revealed that Co administration resulted amelioration most adverse effects associated infection reflected significantly decreased oxidative stress, improved profiles.

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