Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex

摘要: Protein synthesis, which proceeds through three distinct phases – initiation, elongation and termination is the most energetically expensive process in cell accordingly tightly regulated. In mammals, translational control primarily exerted at level of ribosome recruitment during initiation phase. This critical regulatory step often targeted viral infection, developmental processes, regulation proliferation growth, malignant progression. Under circumstances, mRNA to 43S translation complex rate limiting represents a major node for regulating cellular gene expression. Mechanisms have advantage being much more rapid onset than those targeting nuclear events are also capable exerting spatial over expression specific proteins. ribosomes governed by assembly activity eIF4F complex, under mTOR kinase. A wealth evidence from studies experimental cancer models human tissues has now accumulated invoking role elevated development progression highlighting this as target novel anti-cancer therapeutics.