The effect of gamma radiation and neocarzinostatin of NAD and ATP levels in mouse leukaemia cells

作者: P.M. Goodwin , P.J. Lewis , M.I. Davies , C.J. Skidmore , S. Shall

DOI: 10.1016/0304-4165(78)90312-4

关键词:

摘要: Abstract When mouse leukaemia cells are treated with γ-radiation or neocarzinostatin the intracellular NAD and ATP levels fall rapidly. We have shown that response is a consequence of decreased level. suggest this low level results in glycolytic activity there subsequent accumulation phosphorylated sugars associated ATP. Under these extreme conditions, therefore, probably regulates rate glycolysis which utilising rapidly metabolisable sugar as their energy source.

参考文章(16)
W. A. Creasey, L A Stocken, The effect of ionizing radiation on nuclear phosphorylation in the radio-sensitive tissues of the rat Biochemical Journal. ,vol. 72, pp. 519- 523 ,(1959) , 10.1042/BJ0720519
Harry Eagle, Stanley Barban, Mina Levy, Henry O. Schulze, The Utilization of Carbohydrates by Human Cell Cultures Journal of Biological Chemistry. ,vol. 233, pp. 551- 558 ,(1958) , 10.1016/S0021-9258(18)64702-7
M. I. DAVIES, H. HALLDORSSON, S. SHALL, C. J. SKIDMORE, The action of streptozotocin on mouse leukaemia cells. Biochemical Society Transactions. ,vol. 4, pp. 635- 637 ,(1976) , 10.1042/BST0040635
F. Campagnari, J.F. Whitfield, U. Bertazzoni, The effect of X-irradiation on the nicotinamide adenine dinucleotides (NAD-NADH) content of rat thymocytes Experimental Cell Research. ,vol. 42, pp. 646- 656 ,(1966) , 10.1016/0014-4827(66)90277-1
I. Betel, Decreased nucleotide content as the cause of decreased ATP synthesis in thymus nuclei after irradiation. International Journal of Radiation Biology. ,vol. 12, pp. 459- 466 ,(1967) , 10.1080/09553006714551061
Elizabeth Maxwell, Gilbert Ashwell, Effect of x-irradiation on phosphorus metabolism in spleen mitochondria. Archives of Biochemistry and Biophysics. ,vol. 43, pp. 389- 398 ,(1953) , 10.1016/0003-9861(53)90134-9
M. Hinz, N. Katsilambros, V. Maier, H. Schatz, E.F. Pfeiffer, Significance of streptozotocin induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets FEBS Letters. ,vol. 30, pp. 225- 228 ,(1973) , 10.1016/0014-5793(73)80656-8