Cutaneous Human Papillomaviruses

摘要: Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about has recently reported by us. Our characterisation subtype HPV38b[FA125] and the identification several isolates representing putative considerably extended knowledge this taxon. Cutaneous are frequently found in healthy skin some types also implicated non-melanoma cancer immunocompetent well immunosuppressed individuals. However, data on whether these infections persist over time is limited. We that a cohort renal transplant recipients matched controls, 43% (19/44) cutaneous persisted after 6.3 years. we did not detect any significant association between persistent age, sex, immunosuppressive treatment, history warts, or genus HPV. The heterogeneity HPVs, especially Beta-papillomavirus, through our three new types, HPV93, 96, 107. prevalence HPV38 its described HPV92, was analysed lesions paired skin. All were only detected low amounts viral loads. binding ability E7 protein 93 96 tumour suppressor Rb suggests possible role for development cancer. (Less)