Functional role for cortical-striatal circuitry in modulating alcohol self-administration.

摘要: The cortical-striatal brain circuitry is heavily implicated in drug-use. As such, the present study investigated functional role of modulating alcohol self-administration. Given that a for nucleus accumbens core (AcbC) alcohol-reinforced responding has been established, we sought to test cortical regions with afferent projections AcbC: medial prefrontal cortex (mPFC) and insular (IC). Long-Evans rats were trained self-administer (15% (v/v)+2% sucrose (w/v)) during 30 min sessions. To mPFC or IC, utilized chemogenetic technique (hM4Di-Designer Receptors Activation by Designer Drugs) silence neuronal activity prior an self-administration session. Additionally, chemogenetically silenced mPFC→AcbC IC→AcbC projections, investigate Chemogenetically silencing decreased self-administration, while IC increased effect absent mCherry-Controls. Interestingly, had no on In contrast, reinforcer-specific manner as there was (0.8%, w/v). change observed Together these data demonstrate complex implicating insula-striatal circuit ongoing