The Cortisol Awakening Response in Bipolar Illness: A Pilot Study
作者： Dorian Deshauer , Anne Duffy , Martin Alda , Eva Grof , Joy Albuquerque
DOI: 10.1177/070674370304800706
关键词:
摘要: Objectif : Un ensemble de donnees croissantes suggerent qu'une reaction cortisol salivaire significativement accrue au reveil peut indiquer une tendance durable a regulation anormale du cortisol. Notre objectif consistait appliquer le test population deja reputee avoir un dereglement long terme l'axe hypothalamo-hypophyso-surrenalion (HHS). Nous avons emis l'hypothese que la libre reveil, l'on croit d'influence genetique, serait elevee chez pourcentage significatif cas, peu importe valeur l'apres-midi l'epreuve freinage dexamethasone (EFD) Methode teste 18 sujets cliniquement stables et reagissant bien lithium notre suivi naturaliste d'EFD mensuelles, l'aide profil jour court. Ces tests comprenaient analyse salive toutes les 15 minutes durant premiere heure suivie d'echantillons preleves h 20 h. Resultats Bien traitement lithium, patients souffrant trouble bipolaire (TB) ont montre comparativement aux temoins (P < 0,03), Les niveaux cortisol, 30 apres excedaient vaste quantite normatives fournies par documentation 0,001). Conclusions: Nos observations soutiennent selon laquelle reflete an relativement HHS, meme lorsque soufftant TB sont leurs EFD normales. Parce ce est facile administrer, matinale promettre constituer marqueur pour etudes des familles risque eleve l'humeur, ou qui y predisposees.
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