Humoral Innate Immune Effector Responses

摘要: In this chapter, components from the humoral arm of innate immune system are addressed which—in terms a crosstalk—must remain in delicate balance to cellular ensure efficient detection and response both infectious sterile cell stress/tissue injury. Emphasis is put on description prototypical complement that operates together with its co-players, collectins, ficolins, pentraxins. The activation via three convergent pathways, classical pathway, lectin alternative described by focusing molecular structural basis regulation these pathways. Some typical mechanisms involved cascades reviewed especially alluding formation C3 C5 convertases, action anaphylatoxins, membrane attack complex, role receptors, crosstalk between other pattern recognition molecules. A particular subchapter devoted pentraxins which, as “antibody-like molecules,” may be regarded ancestors antibodies determined have rather regulatory function inflammation. final deals antimicrobial peptides such defensins, cathelicidins, histatins. As products activated cells system, they participate first line host defense against pathogenic infections can also key ancient system. There increasing interest substances, “nature’s antibiotics” because show promise overcoming growing problem antibiotic resistance.