The manifold of vitamin B6 dependent enzymes

作者: Gunter Schneider , Helena Käck , Ylva Lindqvist

DOI: 10.1016/S0969-2126(00)00085-X

关键词:

摘要: Abstract Pyridoxal-5′-phosphate (vitamin B 6 ) binding enzymes form a large superfamily that contains at least five different folds. The availability of an increasing number known three-dimensional structures for members this has allowed detailed structural classification. Most progress been made with the fold type I or aspartate aminotransferase family.

参考文章(50)
Sangkee Rhee, Kevin D. Parris, C. Craig Hyde, S. Ashraf Ahmed, Edith Wilson Miles, David R. Davies, Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry. ,vol. 36, pp. 7664- 7680 ,(1997) , 10.1021/BI9700429
C C Hyde, S A Ahmed, E A Padlan, E W Miles, D R Davies, Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium. Journal of Biological Chemistry. ,vol. 263, pp. 17857- 17871 ,(1988) , 10.1016/S0021-9258(19)77913-7
Hideyuki Hayashi, Pyridoxal Enzymes: Mechanistic Diversity and Uniformity Journal of Biochemistry. ,vol. 118, pp. 463- 473 ,(1995) , 10.1093/OXFORDJOURNALS.JBCHEM.A124931
Frederick W. ALEXANDER, Erika SANDMEIER, Perdeep K. MEHTA, Philipp CHRISTEN, Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes FEBS Journal. ,vol. 219, pp. 953- 960 ,(1994) , 10.1111/J.1432-1033.1994.TB18577.X
Akihiro Okamoto, Taiichi Higuchi, Ken Hirotsu, Seiki Kuramitsu, Hiroyuki Kagamiyama, X-Ray Crystallographic Study of Pyridoxal 5′-Phosphate-Type Aspartate Aminotransferases from Escherichia coli in Open and Closed Form Journal of Biochemistry. ,vol. 116, pp. 95- 107 ,(1994) , 10.1093/OXFORDJOURNALS.JBCHEM.A124509
Robert A. John, Pyridoxal phosphate-dependent enzymes Biochimica et Biophysica Acta. ,vol. 1248, pp. 81- 96 ,(1995) , 10.1016/0167-4838(95)00025-P
M. Hennig, B. Grimm, R. Contestabile, R. A. John, J. N. Jansonius, Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 4866- 4871 ,(1997) , 10.1073/PNAS.94.10.4866
Paola Storici, Guido Capitani, Daniela De Biase, Markus Moser, Robert A. John, Johan N. Jansonius, Tilman Schirmer, Crystal Structure of GABA-Aminotransferase, a Target for Antiepileptic Drug Therapy† Biochemistry. ,vol. 38, pp. 8628- 8634 ,(1999) , 10.1021/BI990478J
Robert D. Bach, Carlo Canepa, Mikhail N. Glukhovtsev, Influence of Electrostatic Effects on Activation Barriers in Enzymatic Reactions: Pyridoxal 5‘-Phosphate-Dependent Decarboxylation of α-Amino Acids Journal of the American Chemical Society. ,vol. 121, pp. 6542- 6555 ,(1999) , 10.1021/JA9907616
Nick V. Grishin, Margaret A. Phillips, Elizabeth J. Goldsmith, Modeling of the spatial structure of eukaryotic ornithine decarboxylases Protein Science. ,vol. 4, pp. 1291- 1304 ,(1995) , 10.1002/PRO.5560040705