Stilbene derivatives and pharmaceutical compositions containing them

作者: Koji Ohsumi , Takashi Tsuji , Kazuo Ohishi , Yoshihiro Morinaga

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摘要: Stilbene derivatives having the general formula: (I) wherein R1, R2 and R3 each represent an alkyl group 1 to 3 carbon atoms, X represents a hydrogen atom or nitrile group, Y alkyloxy 6 atoms halogen atom, their pharmaceutically acceptable acid addition salts have low toxicity, are water soluble effective as carcinostatic agents.

参考文章(9)
Daniel Lee Rathbone, John Alfred Slack, Roger John Griffin, Charmaine Paulina Quarterman, Substituted diphenylethylenes and analogues or derivatives thereof ,(1992)
Mark Cushman, Dhanapalan Nagarathnam, D. Gopal, Hu Ming He, Chii M. Lin, Ernest Hamel, Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. Journal of Medicinal Chemistry. ,vol. 35, pp. 2293- 2306 ,(1992) , 10.1021/JM00090A021
J.T. Stewart, Synthesis and Biological Evaluation of Substituted α-Phenylcinnamonitriles Journal of Pharmaceutical Sciences. ,vol. 60, pp. 1244- 1245 ,(1971) , 10.1002/JPS.2600600831
Mark Cushman, Dhanapalan Nagarathnam, D. Gopal, Asit K. Chakraborti, Chii M. Lin, Ernest Hamel, Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. Journal of Medicinal Chemistry. ,vol. 34, pp. 2579- 2588 ,(1991) , 10.1021/JM00112A036
Ernest Hamel, Mark S. Cushman, Stilbene derivatives as anticancer agents ,(1993)
Klaus Bronstert, Dietmar Bender, Stilbene compounds use in anionic polymerization ,(1989)
Peter Otto Bentz, Elastomer-forming composition ,(1993)