Locus coeruleus (LC) stimulation augments LHRH release induced by medial preoptic stimulation. Evidence that the major LC stimulatory component enters contralaterally into the hypothalamus.

摘要: Previous studies by others suggest that mid- and hindbrain noradrenergic projections to the hypothalamus may be stimulatory or inhibitory luteinizing hormone releasing (LHRH) release depending upon steroid environment of rat. In present study we reevaluated effects electrical stimulation locus coeruleus (LC) in estrogen-primed ovariectomized (OVX) rats anesthetized with chloral hydrate. This anesthetic agent blocked spontaneous (LH) surges which normally occur estrogen-treated OVX rats. such rats, bilateral LC was ineffective altering basal LH concentrations. Thereafter, evaluated on patterns concentrations plasma induced electrochemical (ECS) medial preoptic nuclei (MPN). Bilateral MPN-ECS a significant rise LH. When bilaterally stimulated for 15 min beginning 30 after MPN stimulation, peak were significantly augmented remained elevated throughout experiment. To learn more how reach regions contain LHRH neurons, right group unilaterally ECS later min. Plasma levels increased activation but no further fall occurred ipsilateral stimulation. final electrochemically this followed contralateral left LC. these animals, above those obtained only unilateral These data demonstrated augments preliminary depolarization neurons ECS. Moreover, from decussate enter hypothalamic containing neurons.