Effects of Dextran Molecular Weight on Red Blood Cell Aggregation

摘要: The reversible aggregation of human red blood cells (RBC) by proteins or polymers continues to be biologic and biophysical interest, yet the mechanistic details governing process are still being explored. Although a depletion model with osmotic attractive forces due polymer near RBC surface has been proposed for neutral polyglucose dextran, its applicability at high molecular mass not established. In this study, was measured over wide range dextran (70 kDa 28 MDa) concentrations ≤2 g/dL. Our results indicate that does monotonically increase size; instead, it demonstrates an optimum around 200-500 kDa. We used depletion-mediated calculate expected energies. This found consistent experimental thus provides new insight into polymer-RBC interactions.